The First Innovations
Taddeo Alderotti of Florence (1215-1302), in the Vatican codex Consilia of 1276, described in detail the production of aquavitae obtained from wine through double distillations. Alderotti is also the first to mention the serpentine immersed in cold water for the condensation of vapors. Between the 13th and 14th centuries, the water cooling system appeared. The spout of the capital, instead of ending directly in the vessel collecting the distillate, was passed through a small barrel filled with cold water; this would be discussed by the Sienese Andrea Mattioli (1570 - 1577), an important scholar and philologist, a few centuries later.
Venice, the pearl of the Adriatic, played a significant role in the commercialization of spirits. Distillation spread in the Veneto region between the 12th and 13th centuries, when Venice was an important market for wine aquavitae and grape marc, which were exported to Germany and the East, as remedies for the plague and gout.
By the end of the 13th century, the preparation of wine aquavitae became popular, when the Paduan physician Michele Savonarola (1385-1468) published the first treatise on its preparation, the "De Conficienda Aqua Vitae," considered a fundamental document in the history of distillation, as it promoted the practice, knowledge, and use of aqua vitae.
One legendary alchemist is considered to be the link between medieval alchemy and Renaissance medical chemistry: Theopharst Bombast von Hohenheim, also called Paracelso (1493-1541). He was the first to use the term alcohol, with the meaning of excellent refinement, as a synonym for wine spirit or aqua ardens.